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Comprehensive physical-chemical metrics for CAS No. 68333-82-4 (Cocoyl Monoisopropanolamine)
Cocamide MIPA (Cocoyl Monoisopropanolamine), classified under CAS No. 68333-82-4, is a vegetable-derived nonionic amide surfactant that has become the gold standard rheology modifier in modern personal care formulations. Unlike standard alkanolamides such as Cocamide DEA (Diethanolamine), Cocamide MIPA does not contain secondary amines. It is completely nitrosamine-free, meeting the strict cosmetic regulatory frameworks of the European Union, the United States (FDA), and China's NMPA.
By utilizing monoisopropanolamine instead of diethanolamine in the synthesis route, the risk of forming carcinogenic nitrosamines is mitigated. This makes Cocamide MIPA the premier choice for cosmetic brands seeking to comply with Prop 65 and clean-label benchmarks, while retaining top-tier viscosity-building, emulsion-stabilizing, and lather-boosting characteristics.
| Parameters | Specifications |
|---|---|
| Chemical Name | Cocamide Monoisopropanolamine (Cocamide MIPA) |
| CAS Registry Number | 68333-82-4 |
| Molecular Formula | R-CO-NH-CH2-CH(OH)-CH3 (R = Coconut alkyl group) |
| Appearance (25°C) | White to Off-White waxy solid flakes |
| Active Matter | ≥ 95.0% |
| Free Amine Value | ≤ 18.0 mg KOH/g |
| Free Fatty Acid | ≤ 3.0% |
| Melting Point | 45°C – 55°C |
The strategic shift towards non-toxic, plant-based surfactants in personal care chemistry
International regulatory agencies, particularly CIR and SCCS, have continuously restricted secondary amines in cosmetics due to the risk of nitrosation. Cocamide MIPA contains no secondary amines, serving as a drop-in replacement that eliminates the risk of forming nitrosamines while retaining high foaming performance.
In sulfate-free shampoo systems (utilizing Glutamate, Sarcosinate, or Taurate surfactants), standard salt adjustment is highly ineffective for thickening. Cocamide MIPA exhibits outstanding synergy with mild anionic surfactants, yielding high viscosity values without requiring excess salts.
Global multi-nationals require certified sustainable supply chains. Our production facilities source pure coconut oils that comply with eco-certifications. This guarantees the low-carbon footprints, high biodegradability index, and ecological sustainability demanded by conscious consumers.
Why sourcing Cocamide MIPA from Suzhou Yuantairun Chemical offers unmatched competitiveness
At Suzhou Yuantairun Chemical Co., Ltd., our manufacturing setup utilizes precise, automated loop reactors for the catalytic condensation of refined coconut oil and monoisopropanolamine. This precise temperature control reduces color degradation and keeps free amines and raw acids at trace limits.
Our strategic proximity to key ports like Shanghai allows for streamlined shipping and reduced freight timelines. Backed by in-house R&D centers, we provide comprehensive technical support for formulation matching, viscosity adjustments, and custom packaging sizes to suit different manufacturing requirements.
Practical application routes for Cocamide MIPA across varied product classes
In-depth responses resolving the core processing and compliance issues faced by cosmetic chemists
A: Cocamide DEA is derived from diethanolamine, which possesses a secondary amine group susceptible to nitrosation (reacting with nitrates or nitrogen oxides to form carcinogenic nitrosamines). Cocamide MIPA is derived from monoisopropanolamine, a branched primary amine that does not undergo nitrosation. Functionally, Cocamide MIPA is more solid at room temperature (flakes/wax), provides higher thickening efficiency at lower usage rates, and delivers a denser, more stable foam structure.
A: Since Cocamide MIPA has a melting point of approximately 45°C to 55°C, it cannot be added directly to cold water. For cold-process production, it is typically co-melted with the primary surfactants (such as CAPB or mild anionic surfactant concentrates) at around 60°C. Once the mixture is uniform and liquid, it can be diluted with water and cooled down while maintaining steady mechanical agitation.
A: The standard usage rate varies from 0.5% to 3.0% by weight of the active formulation. In standard shampoos and body washes, 1.0% to 1.5% is typically sufficient to achieve the desired viscosity and lather stability. In solid syndet bar formulations, the concentration can go up to 5% to serve as a binding agent.
A: Yes, it is fully compatible. Being nonionic, Cocamide MIPA does not react with cationic materials like Polyquaternium-7, Polyquaternium-10, or Guar Hydroxypropyltrimonium Chloride. In fact, it often acts as a deposition aid, enhancing the conditioning effects of cationic polymers on hair keratin.
A: Our material is produced under strict ISO 9001 and ISO 14001 guidelines. The plant-derived starting materials align with clean beauty standards, and we can provide documentation confirming that it is free of dioxane, residual Solvents, and heavy metals, ensuring compliance with global regulations.
Your strategic chemical raw material supply partner in China
As a leading supplier in the daily chemical raw materials industry, Suzhou Yuantairun Chemical Co., Ltd. is dedicated to delivering high-quality products and comprehensive one-stop services to support our customers in R&D, production, and supply chain optimization. Our mission is to drive innovation and efficiency in the global daily chemical industry by providing cutting-edge solutions tailored to our clients' needs.
We assure you that our products originate from well-managed and sustainable resources, providing the stability and traceability required for modern cosmetic formulations.
We provide a comprehensive range of surfactants, rheology modifiers, and functional actives to simplify raw material sourcing.
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Proven formulations designed to address distinct market requirements
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Combines amphoteric CAB-35 (Cocamidopropyl Betaine) and non-ionic APG1214 (Lauryl Glucoside) for rich, low-residue lather. Sulfate-free formula minimizes skin dryness.
Powered by LAS (Linear Alkylbenzene Sulfonate) and solvent EGDS for rapid breakdown of tough grease, meeting demanding industrial wastewater regulations.
We customize formulation profiles based on your use scenario, such as hotels, barbershops, or retail, offering multi-functional packaging options.
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