Potassium Capryl Glycyrrhizinate (PCG) is an amphiphilic derivative of glycyrrhizic acid, the primary bioactive compound extracted from the roots of Licorice (Glycyrrhiza glabra / Glycyrrhiza uralensis). Unlike conventional hydrophilic glycyrrhizic acid salts (such as Dipotassium Glycyrrhizinate), PCG undergoes strategic esterification with a medium-chain caprylic group. This molecular hybridization introduces a lipophilic tail that drastically enhances the active's transdermal bioavailability, allowing it to easily integrate into and penetrate the lipid bilayers of the stratum corneum.
Once absorbed, PCG exerts a powerful inhibitory response on the NF-κB signaling pathway, downregulating the expression of pro-inflammatory cytokines such as IL-1α, IL-6, and TNF-α. This mechanism makes PCG an invaluable active ingredient in modern dermatological and cosmetic formulations aimed at resolving micro-inflammatory stress, suppressing erythema, and accelerating the reconstruction of compromised skin barriers.
As a leading research-driven factory, we synthesize Potassium Capryl Glycyrrhizinate using advanced, environmentally safe green chemistry pathways. This ensures high purity, consistent batch-to-batch composition, and minimal ecological footprint.
INCI Name: Potassium Capryl Glycyrrhizinate
Purity Assay (HPLC): ≥ 98.0%
Appearance: Off-white to pale yellow fine powder
Solubility: Amphiphilic (dispersible in water, soluble in polar lipids and glycols)
Recommended Dosage: 0.1% – 1.0%
Optimum pH Stability Range: 5.0 – 7.5
How industrial chemical factories resolve formulation challenges by integrating bio-based, high-efficacy active agents like PCG.
Modern consumers actively avoid synthetic cortisones and harsh skin-soothing agents. Our high-purity PCG offers a 100% natural, botanically derived alternative that delivers clinically proven soothing effects without the risk of thinning the skin or inducing dependency.
Traditional licorice extracts are notorious for causing phase separation or discoloration in shampoos and facial washes. Because PCG features a caprylic lipophilic group, it blends perfectly with anionic and amphoteric surfactants, remaining stable across varying temperatures.
Sensitive skin reactions are often caused by overstimulated sensory neurons in the skin. PCG acts as a biological shield, lowering the activation threshold of TRPV1 channels, thereby reducing burning, stinging, and itching sensations in reactive skin types.
The global demand for high-efficacy, bio-based dermatological ingredients is growing at an unprecedented CAGR of 8.4%. Specifically, glycyrrhizinate derivatives have moved from basic skincare into clinical-grade cosmeceuticals, post-procedure recovery creams, and high-performance baby care formulas.
To meet this rising demand, our factory uses advanced extraction and purification machinery. Our annual production capacity for Potassium Capryl Glycyrrhizinate exceeds 200 metric tons, making us a key supplier for global cosmetic brands, contract manufacturers (ODMs/OEMs), and distributors across North America, the EU, and APAC.
Through vertically integrated sourcing partnerships, we guarantee that all wild-harvested and farmed licorice roots come from sustainable resources, preventing soil depletion in arid cultivation zones.
Exporting raw chemical materials requires strict adherence to international safety and quality standards.
We provide our international clients with full documentation packages to ensure smooth regulatory clearance and formulation approval. This includes: Material Safety Data Sheets (MSDS), Certificates of Analysis (COA) per batch, TSE/BSE Free Certificates, GMO-Free Declarations, and complete heavy metal & pesticide residue testing sheets. We also offer full technical support to help you smoothly integrate our ingredients into your existing formulas.
Discover how to incorporate Potassium Capryl Glycyrrhizinate into different cosmetic and personal care products.
Perfect for sensitive skin formulations. Combine 0.2% PCG with amino acid surfactants like Disodium Cocoyl Glutamate. The lipophilic tail of PCG integrates into the surfactant micelles, reducing irritation and leaving the skin feeling hydrated and balanced.
For anti-redness or post-procedure repair creams, use 0.5% PCG in an oil-in-water emulsion stabilized with Caprylic/Capric Triglyceride. It quickly penetrates the skin barrier to calm inflammation, reduce redness, and soothe irritation.
PCG helps regulate excess sebum production while calming acne-related inflammation. Adding 0.3% PCG to lightweight gels or toner formulations targets acne breakouts, reducing swelling and redness without drying out the skin.
Our long-term R&D roadmap focuses on improving the efficiency and sustainability of our manufacturing processes. We are currently shifting our esterification reactions from traditional acid-catalyzed methods to enzyme-catalyzed biotransformations. This enzymatic process allows us to run synthesis at lower temperatures, reducing energy consumption and eliminating unwanted byproducts.
Additionally, we are exploring nano-delivery systems, such as solid lipid nanoparticles (SLNs), to further improve the stability and absorption of Potassium Capryl Glycyrrhizinate in water-based cosmetic formulations. This will allow formulators to achieve even higher efficacy at lower concentration levels.
Professional technical answers for formulation scientists and cosmetic R&D specialists.
Founded in 2010, Suzhou Yuantairun Chemical Co., Ltd. (YuantaiRun) has grown into a leading supplier in the daily chemical raw materials industry. We are dedicated to providing high-quality products and comprehensive one-stop services to support our global partners in R&D, production, and supply chain optimization.
Our mission is to drive innovation and efficiency in the global daily chemical industry by providing cutting-edge solutions tailored to our clients' needs. Today, we work with over 7,000 cooperative partners worldwide, supplying reliable ingredients that power some of the world's most trusted personal care brands.
We provide a comprehensive portfolio of high-quality cosmetic and detergent ingredients to simplify your sourcing process.
Our fully equipped labs offer ODM and OEM services, helping you customize formulas to meet specific market demands.
By optimizing our manufacturing and supply chain, we deliver premium-grade materials at highly competitive prices.
We align our supply chain with your production schedule, ensuring raw materials arrive exactly when they are needed.
We work closely with manufacturers to create targeted solutions for home, personal, and industrial care:
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Developing gentle facial cleansers and body washes featuring Sodium Cocoyl Glutamate and Sodium Lauroyl Sarcosinate for sensitive skin protection.
Compounding high-performance industrial cleaners using LAS, non-ionic surfactants, and specialized enzymes to rapidly break down heavy oils and grease.
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